Atom probe tomography (APT) has an exciting potential to provide truly unique insights to biomaterials research, such as teeth, bone and synthetic implants. APT could provide a 3D representation of composition and improve our understanding of tissues-biomaterial interface. For example, understanding the long-standing questions of the strontium uptake in bone from strontium-loaded bioactive glass scaffolds which is powerful for the repair of significant bone defects. In my research, ATP specimen preparation, experiments, 3D image reconstruction and data analyse will be developed for reliable and routine biomaterial characterisation. APT will be utilized to study the Sr uptake in bone from a newly developed bioactive glass scaffold to catalyse repair of substantial defects. And we will try to establish expertise to support ongoing biomaterials research, providing a 3D atomic scale characterisation tool to complement other higher resolution microscope techniques.